Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 7/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGFR | P43088 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGIR | P43119 | 1/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527261 | 0.87 | AGTR2 (0.53) | AGTR2AGTR1 | |
| SCHEMBL9526329 | 0.85 | AGTR1 (0.49) | AGTR2AGTR1 | |
| SCHEMBL9527786 | 0.83 | AGTR2 (0.47) | AGTR2AGTR1TBXA2RPTGER1PTGER4 | |
| SCHEMBL9526953 | 0.83 | AGTR2 (0.47) | AGTR2AGTR1TBXA2RPTGER1PTGER4 | |
| SCHEMBL9529961 | 0.82 | AGTR2 (0.57) | AGTR2AGTR1 | |
| SCHEMBL9753975 | 0.81 | AGTR2 (0.46) | AGTR2AGTR1 | |
| SCHEMBL9527302 | 0.80 | AGTR1 (0.46) | AGTR2AGTR1 | |
| SCHEMBL9531915 | 0.78 | AGTR2 (0.46) | AGTR2AGTR1 | |
| SCHEMBL9526726 | 0.78 | AGTR1 (0.50) | AGTR2AGTR1TBXA2RPTGER1PTGER4 | |
| SCHEMBL9526538 | 0.75 | AGTR2 (0.39) | AGTR2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0523141-A4 | SUBSTITUTED PYRAZOLES, ISOXAZOLES AND ISOTHIAZOLES | — | 1993-04-21 | — | — | EP | claimed |
| EP-0523141-A1 | SUBSTITUTED PYRAZOLES, ISOXAZOLES AND ISOTHIAZOLES | MERCK & CO. INC. (US) | 1993-01-20 | — | — | EP | claimed |
| WO-1991015479-A1 | SUBSTITUTED PYRAZOLES, ISOXAZOLES AND ISOTHIAZOLES | MERCK & CO., INC. (US) | 1991-10-17 | — | — | WO | claimed |
| EP-0523141-A4 | SUBSTITUTED PYRAZOLES, ISOXAZOLES AND ISOTHIAZOLES | — | 1993-04-21 | — | — | EP | disclosed |
| EP-0523141-A1 | SUBSTITUTED PYRAZOLES, ISOXAZOLES AND ISOTHIAZOLES | MERCK & CO. INC. (US) | 1993-01-20 | — | — | EP | disclosed |
| WO-1991015479-A1 | SUBSTITUTED PYRAZOLES, ISOXAZOLES AND ISOTHIAZOLES | MERCK & CO., INC. (US) | 1991-10-17 | — | — | WO | disclosed |