Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | TAOK3 | Q9H2K8 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9528112 | 0.88 | MTNR1A (0.42) | MTNR1AMTNR1BSLC6A4MAOAMAOB | |
| SCHEMBL9243758 | 0.84 | MTNR1A (0.51) | MTNR1AMTNR1B | |
| SCHEMBL9531034 | 0.81 | MTNR1A (0.44) | MTNR1AMTNR1BMAOAMAOBGRIN2B | |
| SCHEMBL9776910 | 0.74 | GRIN2B (0.54) | MTNR1AMTNR1BSLC6A4GRIN2BSIGMAR1 | |
| SCHEMBL9240988 | 0.74 | MTNR1A (0.49) | MTNR1AMTNR1B | |
| SCHEMBL9759575 | 0.72 | MTNR1A (0.43) | MTNR1AMTNR1B | |
| SCHEMBL9776908 | 0.70 | MTNR1A (0.42) | MTNR1AMTNR1BSLC6A4MAOAKMT2A | |
| SCHEMBL9239575 | 0.69 | MTNR1A (0.51) | MTNR1AMTNR1B | |
| SCHEMBL13996919 | 0.68 | DRD2 (0.62) | MTNR1AMTNR1BMAOAMAOBGRIN2B | |
| SCHEMBL8674717 | 0.67 | MTNR1A (0.39) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0270947-B1 | SUBSTITUTED BASIC 2-AMINOTETRALINES | BAYER AG (DE) | 1993-05-19 | — | — | EP | disclosed |
| EP-0270947-A2 | Substituted basic 2-aminotetralines | BAYER AG (DE) | 1988-06-15 | — | — | EP | disclosed |