Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9239575 | 0.86 | MTNR1A (0.51) | MTNR1AMTNR1BCYP1A2CYP2C9DRD2 | |
| SCHEMBL9530209 | 0.81 | MTNR1A (0.44) | MTNR1AMTNR1BMAOAMAOBGRIN2B | |
| SCHEMBL9759575 | 0.79 | MTNR1A (0.43) | MTNR1AMTNR1BCYP1A2CYP2C9DRD2 | |
| SCHEMBL9528112 | 0.79 | MTNR1A (0.42) | MTNR1AMTNR1BMAOAMAOBGRIN2B | |
| SCHEMBL8674717 | 0.74 | MTNR1A (0.39) | MTNR1AMTNR1BCYP1A2CYP2C9DRD2 | |
| SCHEMBL9759071 | 0.71 | MTNR1A (0.42) | MTNR1AMTNR1BCYP1A2CYP2C9DRD2 | |
| SCHEMBL9243758 | 0.69 | MTNR1A (0.51) | MTNR1AMTNR1BCYP1A2CYP2C9DRD2 | |
| SCHEMBL13996919 | 0.68 | DRD2 (0.62) | MTNR1AMTNR1BMAOAMAOBGRIN2B | |
| SCHEMBL9776910 | 0.67 | GRIN2B (0.54) | MTNR1AMTNR1BGRIN2BSIGMAR1DRD2 | |
| SCHEMBL9185060 | 0.67 | DRD2 (0.55) | MTNR1AMTNR1BCYP1A2CYP2C9DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0270947-B1 | SUBSTITUTED BASIC 2-AMINOTETRALINES | BAYER AG (DE) | 1993-05-19 | — | — | EP | disclosed |
| EP-0270947-A2 | Substituted basic 2-aminotetralines | BAYER AG (DE) | 1988-06-15 | — | — | EP | disclosed |