Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9530044 | 0.89 | ABCB1 (0.49) | SIGMAR1DRD2DRD4ADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL10368330 | 0.88 | ABCB1 (0.48) | SIGMAR1DRD2DRD4ADRA2AADRA2B | |
| SCHEMBL9455118 | 0.85 | ADRA2A (0.70) | DRD2DRD4ADRA2AADRA2BADRA2C | |
| SCHEMBL9455117 | 0.81 | CASR (0.45) | SIGMAR1DRD2DRD4ADRA2AADRA2B | |
| SCHEMBL9455324 | 0.81 | ADRA2A (0.66) | DRD2DRD4ADRA2AADRA2BADRA2C | |
| SCHEMBL9696810 | 0.80 | ADRA2A (0.59) | SIGMAR1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9529266 | 0.79 | DRD2 (0.53) | SIGMAR1DRD2DRD4GRM2HTR1A | |
| SCHEMBL9455287 | 0.77 | ADRA2A (0.59) | DRD2DRD4ADRA2AADRA2BADRA2C | |
| SCHEMBL9529716 | 0.76 | KCNH2 (0.50) | DRD2DRD4ADRA2AADRA2BADRA2C | |
| SCHEMBL9455184 | 0.75 | ADRA2A (0.59) | DRD2DRD4ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359790-B1 | 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ERBA CARLO SPA (IT) | 1993-11-03 | — | — | EP | disclosed |
| US-5084454-A | Tranquilizers and antinausea drugs | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-01-28 | — | — | US | disclosed |