Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 9/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 8/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 8/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 7/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9455287 | 0.96 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CMAPK1ADRA1A | |
| SCHEMBL9455324 | 0.94 | ADRA2A (0.66) | ADRA2AADRA2BADRA2CMAPK1ADRA1A | |
| SCHEMBL9455118 | 0.87 | ADRA2A (0.70) | ADRA2AADRA2BADRA2CADRA1ADRD2 | |
| SCHEMBL9530260 | 0.75 | SIGMAR1 (0.53) | ADRA2AADRA2BADRA2CADRA1ADRD2 | |
| SCHEMBL9455290 | 0.75 | SIGMAR1 (0.62) | — | |
| SCHEMBL2550479 | 0.74 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1AHTR1A | |
| SCHEMBL27806422 | 0.73 | ADRA1A (0.76) | ADRA2AADRA2BADRA2CADRA1ADRD2 | |
| SCHEMBL9455188 | 0.73 | L3MBTL1 (0.44) | MAPK1DRD2HTR1AMEN1ALDH1A1 | |
| SCHEMBL9530044 | 0.72 | ABCB1 (0.49) | ADRA2AADRA2BADRA2CADRA1ADRD2 | |
| SCHEMBL9455321 | 0.71 | SIGMAR1 (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359790-B1 | 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ERBA CARLO SPA (IT) | 1993-11-03 | — | — | EP | disclosed |
| US-5229383-A | Treating psychotic disorders | FARMITALIA CARLO ERBA S.R.L. (IT) | 1993-07-20 | — | — | US | disclosed |
| US-5084454-A | Tranquilizers and antinausea drugs | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-01-28 | — | — | US | disclosed |
| EP-0359790-A1 | 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION. | ERBA CARLO SPA (IT) | 1990-03-28 | — | — | EP | disclosed |
| WO-1989007596-A1 | NEW 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-08-24 | — | — | WO | disclosed |