Sugi Predict

Sugi Predict / Compounds / SCHEMBL9530690

SCHEMBL9530690

SCHEMBL9530690

OC1=C(O)Oc2ccccc2O1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AHR P35869 5/20 0.57
▸ MAOA P21397 2/20 0.42
▸ MAOB P27338 2/20 0.42
▸ ALOX5 P09917 1/20 0.39
▸ CA12 O43570 2/20 0.39
▸ CA2 P00918 2/20 0.39
▸ CA3 P07451 2/20 0.39
▸ CA4 P22748 2/20 0.39
▸ TDP1 Q9NUW8 2/20 0.39
▸ CA14 Q9ULX7 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ GMNN O75496 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ EGFR P00533 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ FYN P06241 1/20 0.39
▸ POLB P06746 1/20 0.39
▸ CYP3A4 P08684 1/20 0.39
▸ MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5588066 0.79 AHR (0.70) AHRMAOAMAOBALOX5ALDH1A1
SCHEMBL23682874 0.79 AHR (0.56) AHRMAOAMAOBALOX5CA12
SCHEMBL5587873 0.79 AHR (0.44) AHRMAOAMAOBALOX5CA2
SCHEMBL5590092 0.79 AHR (0.44) AHRMAOAMAOBALOX5KDM4E
SCHEMBL29724179 0.78 MAOA (0.56) AHRMAOAMAOBALOX5KDM4E
SCHEMBL29383458 0.78 MAOA (0.56) AHRMAOAMAOBALOX5KDM4E
SCHEMBL4571011 0.78 MAOA (0.56) AHRMAOAMAOBALOX5KDM4E
SCHEMBL3102452 0.78 MAOA (0.56) AHRMAOAMAOBALOX5KDM4E
SCHEMBL8668546 0.78 MAOA (0.56) AHRMAOAMAOBALOX5KDM4E
SCHEMBL125113 0.78 MAOA (0.56) AHRMAOAMAOBALOX5KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0235523-A2 Dichlorobenzodioxenes BAYER AG (DE) 1987-09-09 — — EP claimed
US-20230116770-A1 SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF Sanford Burnham Prebys Medical Discovery Institute 2023-04-13 — — US disclosed
US-11452717-B2 Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof Sanford Burnham Prebys Medical Discovery Institute (US) 2022-09-27 — — US disclosed
EP-0359290-B1 AROMATIC DIOLS GLAXO GROUP LIMITED (GB) 1993-08-04 — — EP disclosed
EP-0359290-A1 Aromatic diols GLAXO GROUP LIMITED (GB) 1990-03-21 — — EP disclosed
EP-0235523-A2 Dichlorobenzodioxenes BAYER AG (DE) 1987-09-09 — — EP disclosed
EP-0235523-A2 Dichlorobenzodioxenes BAYER AG (DE) 1987-09-09 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11452717-B2 Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof NAMPT, NAPRT, NNT AHR 2333/4885MAOA 561/4885MAOB 531/4885
US-20230116770-A1 SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF NAMPT, NAPRT, NNT AHR 2333/4885MAOA 561/4885MAOB 531/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.