Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9530208 | 1.00 | TSHR (0.33) | TSHRL3MBTL1CHRM2CHRM4CHRM1 | |
| SCHEMBL26764167 | 0.82 | ALDH1A1 (0.39) | TSHRPOLBALOX15 | |
| SCHEMBL9530410 | 0.81 | PLA2G10 (0.39) | POLB | |
| SCHEMBL23641866 | 0.78 | GAA (0.40) | — | |
| SCHEMBL9534617 | 0.77 | CHRNA7 (0.40) | CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL3593084 | 0.77 | ALDH1A1 (0.55) | TSHRPOLBALOX15 | |
| SCHEMBL9636719 | 0.77 | ALDH1A1 (0.55) | TSHRPOLBALOX15 | |
| SCHEMBL9534142 | 0.75 | POLB (0.36) | TSHRL3MBTL1POLB | |
| SCHEMBL3562356 | 0.73 | POLB (0.37) | TSHRCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL8080652 | 0.73 | POLB (0.37) | TSHRCHRM2CHRM4CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252744-B1 | 3-Beta-(3,4-disubstituted succinimido)azetidinones | LILLY CO ELI (US) | 1993-12-15 | — | — | EP | disclosed |
| US-4734498-A | 3β-succinimidoazetidinones as chiral intermediates | ELI LILLY AND COMPANY (US) | 1988-03-29 | — | — | US | disclosed |
| EP-0252744-A2 | 3-Beta-(3,4-disubstituted succinimido)azetidinones | ELI LILLY AND COMPANY (US) | 1988-01-13 | — | — | EP | disclosed |