Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CACNA1S | Q13698 | 7/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.31 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | SCN1A | P35498 | 1/20 | 0.31 |
| ▸ | SCN4A | P35499 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.31 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.31 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9530208 | 0.75 | TSHR (0.33) | POLBL3MBTL1TSHR | |
| SCHEMBL9530731 | 0.75 | TSHR (0.33) | POLBL3MBTL1TSHR | |
| SCHEMBL23641774 | 0.73 | LMNA (0.39) | POLBCACNA1SSMN1; SMN2CYP3A4TSHR | |
| SCHEMBL23641912 | 0.73 | LMNA (0.39) | POLBCACNA1SSMN1; SMN2CYP3A4TSHR | |
| SCHEMBL2237730 | 0.71 | POLB (0.43) | POLBALDH1A1MEN1KMT2AELANE | |
| SCHEMBL9080425 | 0.71 | POLB (0.43) | POLBALDH1A1MEN1KMT2AELANE | |
| SCHEMBL3681001 | 0.68 | POLB (0.45) | POLBELANE | |
| SCHEMBL7468866 | 0.63 | ALDH1A1 (0.48) | POLBALDH1A1MEN1KMT2A | |
| SCHEMBL13786165 | 0.63 | L3MBTL1 (0.46) | SMN1; SMN2L3MBTL1TSHRMEN1KMT2A | |
| SCHEMBL11479712 | 0.61 | POLB (0.39) | POLBTSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252744-B1 | 3-Beta-(3,4-disubstituted succinimido)azetidinones | LILLY CO ELI (US) | 1993-12-15 | — | — | EP | disclosed |
| US-4734498-A | 3β-succinimidoazetidinones as chiral intermediates | ELI LILLY AND COMPANY (US) | 1988-03-29 | — | — | US | disclosed |
| EP-0252744-A2 | 3-Beta-(3,4-disubstituted succinimido)azetidinones | ELI LILLY AND COMPANY (US) | 1988-01-13 | — | — | EP | disclosed |