Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 2/20 | 0.51 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8424336 | 0.87 | ALDH1A1 (0.56) | TDP1MMP8PIN1L3MBTL1MEN1 | |
| SCHEMBL8424338 | 0.87 | ALDH1A1 (0.56) | TDP1MMP8PIN1L3MBTL1MEN1 | |
| SCHEMBL13699231 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTTDP1MMP8PIN1 | |
| SCHEMBL13699367 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTTDP1MMP8PIN1 | |
| SCHEMBL27707724 | 0.86 | L3MBTL1 (0.52) | SMN1; SMN2MAPTTDP1MMP8PIN1 | |
| SCHEMBL991355 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTTDP1MMP8PIN1 | |
| SCHEMBL614649 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTTDP1MMP8PIN1 | |
| SCHEMBL820513 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTTDP1MMP8PIN1 | |
| SCHEMBL13557796 | 0.81 | TDP1 (0.60) | SMN1; SMN2TDP1L3MBTL1NPC1LMNA | |
| SCHEMBL13557800 | 0.81 | TDP1 (0.60) | SMN1; SMN2TDP1L3MBTL1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252744-B1 | 3-Beta-(3,4-disubstituted succinimido)azetidinones | LILLY CO ELI (US) | 1993-12-15 | — | — | EP | disclosed |
| US-4734498-A | 3β-succinimidoazetidinones as chiral intermediates | ELI LILLY AND COMPANY (US) | 1988-03-29 | — | — | US | disclosed |
| EP-0252744-A2 | 3-Beta-(3,4-disubstituted succinimido)azetidinones | ELI LILLY AND COMPANY (US) | 1988-01-13 | — | — | EP | disclosed |