Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533103 | 0.86 | KMT2A (0.47) | TSHRKDM4EMAPTMAPK1MAOB | |
| SCHEMBL9533227 | 0.79 | ALDH1A1 (0.53) | TSHRMAPTALDH1A1HPGDMEN1 | |
| SCHEMBL9530663 | 0.79 | TSHR (0.40) | TSHRKDM4EMAPTMAPK1MAOB | |
| SCHEMBL9530722 | 0.77 | TDP1 (0.36) | TSHRMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL9532214 | 0.76 | MAOB (0.43) | KDM4EMAPK1MAOBALDH1A1GAA | |
| SCHEMBL9531822 | 0.75 | MAOB (0.43) | KDM4EMAPTMAPK1MAOBALDH1A1 | |
| SCHEMBL8980246 | 0.74 | MEN1 (0.44) | TSHRKDM4EMAPTMAOBALDH1A1 | |
| SCHEMBL10656598 | 0.74 | MAOB (0.36) | TSHRKDM4EMAPTMAPK1MAOB | |
| SCHEMBL10528257 | 0.73 | NPC1 (0.43) | TSHRMAPTALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL9531668 | 0.71 | KDM4E (0.44) | TSHRKDM4EMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277836-B1 | THIAZOLIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR USE | Sankyo Company Limited (JP) | 1993-06-02 | — | — | EP | disclosed |
| US-4873255-A | REDUCE BLOOD GLUCOSE AND BLOOD LIPID LEVELS | SANKYO COMPANY LIMITED (JP) | 1989-10-10 | — | — | US | disclosed |
| EP-0277836-A1 | Thiazolidinone derivatives, their preparation and their use | Sankyo Company Limited (JP) | 1988-08-10 | — | — | EP | disclosed |