Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8172995 | 0.81 | TDP1 (0.43) | TDP1MAPTMEN1KMT2AAKT1 | |
| SCHEMBL8649816 | 0.77 | ALDH1A1 (0.43) | TDP1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9533929 | 0.77 | PPARG (0.39) | TDP1MAPTMEN1KMT2APPARG | |
| SCHEMBL9531218 | 0.77 | TSHR (0.44) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL9530470 | 0.77 | MAPT (0.50) | TDP1MAPTMEN1KMT2ATSHR | |
| SCHEMBL7455277 | 0.76 | ALDH1A1 (0.56) | TDP1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9531820 | 0.75 | AKT1 (0.43) | TDP1MAPTMEN1KMT2AAKT1 | |
| SCHEMBL9531417 | 0.74 | AKT1 (0.47) | AKT1PPARGKCNH2 | |
| SCHEMBL7986932 | 0.73 | MAPT (0.61) | TDP1MAPTMEN1KMT2ATSHR | |
| SCHEMBL9630761 | 0.72 | TDP1 (0.48) | TDP1MAPTMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277836-B1 | THIAZOLIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR USE | Sankyo Company Limited (JP) | 1993-06-02 | — | — | EP | disclosed |
| US-4873255-A | REDUCE BLOOD GLUCOSE AND BLOOD LIPID LEVELS | SANKYO COMPANY LIMITED (JP) | 1989-10-10 | — | — | US | disclosed |
| EP-0277836-A1 | Thiazolidinone derivatives, their preparation and their use | Sankyo Company Limited (JP) | 1988-08-10 | — | — | EP | disclosed |