Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.49 |
| ▸ | DRD3 | P35462 | 5/20 | 0.49 |
| ▸ | DRD4 | P21917 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529877 | 0.86 | DRD2 (0.49) | DRD2DRD3DRD4 | |
| SCHEMBL9528065 | 0.85 | DRD2 (0.35) | DRD2DRD3DRD4 | |
| SCHEMBL9528137 | 0.83 | DRD2 (0.53) | DRD2DRD3DRD4 | |
| SCHEMBL9529734 | 0.81 | DRD2 (0.52) | DRD2DRD3DRD4 | |
| SCHEMBL9529758 | 0.79 | DRD2 (0.38) | DRD2DRD3DRD4 | |
| SCHEMBL9532677 | 0.78 | DRD2 (0.33) | DRD2DRD3DRD4 | |
| SCHEMBL9527835 | 0.77 | ALDH1A1 (0.46) | DRD2DRD3DRD4 | |
| SCHEMBL9528731 | 0.76 | DRD2 (0.52) | DRD2DRD3DRD4 | |
| SCHEMBL6648602 | 0.76 | SIGMAR1 (0.36) | MAPT | |
| SCHEMBL9532675 | 0.75 | GRIN2B (0.36) | DRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556332-A1 | SUBSTITUTED TETRAHYDROPYRIDINES AND HYDROXYPIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS. | WARNER LAMBERT CO (US) | 1993-08-25 | — | — | EP | claimed |
| EP-0556332-A1 | SUBSTITUTED TETRAHYDROPYRIDINES AND HYDROXYPIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS. | WARNER LAMBERT CO (US) | 1993-08-25 | — | — | EP | disclosed |