Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6368536 | 0.97 | SIGMAR1 (0.34) | SIGMAR1HTR2CF2LTB4R | |
| SCHEMBL6650636 | 0.86 | RIPK3 (0.34) | — | |
| SCHEMBL6648116 | 0.83 | KDM4E (0.37) | KDM4EMAPT | |
| SCHEMBL9868832 | 0.81 | SIGMAR1 (0.39) | SIGMAR1HTR2CF2 | |
| Hydrochloric Acid SCHEMBL6586236 | 0.78 | HTR2C (0.41) | SIGMAR1HTR2CF2 | |
| SCHEMBL6648243 | 0.77 | SIGMAR1 (0.36) | SIGMAR1HTR2CF2 | |
| SCHEMBL9532276 | 0.76 | DRD2 (0.49) | MAPT | |
| SCHEMBL9529877 | 0.76 | DRD2 (0.49) | SIGMAR1HTR2C | |
| SCHEMBL9528731 | 0.76 | DRD2 (0.52) | — | |
| SCHEMBL6648237 | 0.75 | LMNA (0.41) | SIGMAR1HTR2CF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1469854-A1 | CONDENSED HETEROCYCLIC COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003063874-A1 | CONDENSED HETEROCYCLIC COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-08-07 | — | — | WO | disclosed |
| EP-0779284-B1 | Novel 2-naphthamide derivatives and their use in therapy as D3 receptor agonists | INST NAT SANTE RECH MED (FR) | 2002-07-10 | — | — | EP | disclosed |
| US-5985895-A | 2-naphthamide derivatives and their therapeutic applications | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE-INSERM (FR) | 1999-11-16 | — | — | US | disclosed |
| US-5872119-A | 2-Naphthamide derivatives and their therapeutic applications | Institut National De La Sante et De La Recherche Medicale--INSERM (FR) | 1999-02-16 | — | — | US | disclosed |
| EP-0779284-A1 | Novel 2-naphthamide derivatives and their use in therapy as D3 receptor agonists | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-06-18 | — | — | EP | disclosed |