Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 6/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | DBH | P09172 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7694500 | 0.84 | PRMT5 (0.30) | — | |
| SCHEMBL7688429 | 0.84 | IL4I1 (0.38) | AGTR1AGTR2 | |
| SCHEMBL9177521 | 0.81 | AGTR1 (0.35) | AGTR1AGTR2 | |
| SCHEMBL9534518 | 0.80 | AGTR1 (0.44) | AGTR1AGTR2 | |
| SCHEMBL8543595 | 0.79 | CASP3 (0.46) | — | |
| SCHEMBL8120413 | 0.78 | ALDH1A1 (0.34) | AGTR1AGTR2ALDH1A1 | |
| SCHEMBL8813188 | 0.76 | AGTR1 (0.36) | AGTR1 | |
| SCHEMBL8812892 | 0.76 | CYP17A1 (0.36) | AGTR1AGTR2 | |
| SCHEMBL446251 | 0.76 | LIMK2 (0.44) | AGTR1AGTR2ALDH1A1 | |
| SCHEMBL9179707 | 0.76 | HTT (0.45) | AGTR1AGTR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555331-A1 | N-SUBSTITUTED IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS. | SEARLE & CO (US) | 1993-08-18 | — | — | EP | disclosed |
| WO-1992007834-A1 | N-SUBSTITUTED IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-05-14 | — | — | WO | disclosed |