Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 7/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9530822 | 0.84 | KDM4E (0.35) | AKT1MAOBMAPTMEN1KMT2A | |
| SCHEMBL10656598 | 0.82 | MAOB (0.36) | AKT1MAOBMAPTMEN1KMT2A | |
| SCHEMBL8980246 | 0.80 | MEN1 (0.44) | AKT1MAOBMAPTMEN1KMT2A | |
| SCHEMBL9531302 | 0.80 | CYP3A4 (0.53) | MAPTMEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL9531921 | 0.80 | AKT1 (0.36) | ESR1ESR2AKT1MAOBMAPT | |
| SCHEMBL11446140 | 0.76 | AKT1 (0.52) | ESR1ESR2AKT1MAPTKDM4E | |
| SCHEMBL9532214 | 0.75 | MAOB (0.43) | MAOBKDM4EALDH1A1GAAHPGD | |
| SCHEMBL7125937 | 0.74 | MEN1 (0.36) | MAPTMEN1KMT2ATDP1KDM4E | |
| SCHEMBL30251078 | 0.72 | ALDH1A1 (0.53) | ESR1ESR2AKT1MAOBMAPT | |
| SCHEMBL1983678 | 0.72 | ALDH1A1 (0.53) | ESR1ESR2AKT1MAOBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277836-B1 | THIAZOLIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR USE | Sankyo Company Limited (JP) | 1993-06-02 | — | — | EP | disclosed |
| US-4873255-A | REDUCE BLOOD GLUCOSE AND BLOOD LIPID LEVELS | SANKYO COMPANY LIMITED (JP) | 1989-10-10 | — | — | US | disclosed |