Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAP1LC3B | Q9GZQ8 | 4/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533291 | 1.00 | PLK1 (0.51) | PLK1CSNK2A1PLK3ALDH1A1SMN1; SMN2 | |
| SCHEMBL9534422 | 0.91 | PLK1 (0.65) | PLK1CSNK2A1PLK3ALDH1A1SMN1; SMN2 | |
| SCHEMBL22980483 | 0.78 | PLK1 (0.79) | PLK1CSNK2A1PLK3ALDH1A1SMN1; SMN2 | |
| SCHEMBL9535703 | 0.72 | PLK1 (0.61) | PLK1CSNK2A1PLK3ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9534437 | 0.70 | PLK1 (0.59) | PLK1CSNK2A1PLK3ALDH1A1SMN1; SMN2 | |
| SCHEMBL6837311 | 0.70 | MAP1LC3B (0.47) | ALDH1A1SMN1; SMN2HIF1AMAPTHTT | |
| SCHEMBL3142557 | 0.68 | PLK1 (0.93) | PLK1CSNK2A1PLK3ALDH1A1SMN1; SMN2 | |
| SCHEMBL1986758 | 0.68 | PLK1 (1.00) | PLK1CSNK2A1PLK3ALDH1A1SMN1; SMN2 | |
| SCHEMBL9211876 | 0.66 | PLK1 (0.50) | PLK1CSNK2A1PLK3ALDH1A1SMN1; SMN2 | |
| SCHEMBL9211872 | 0.66 | PLK1 (0.50) | PLK1CSNK2A1PLK3ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276834-B1 | Cycloalkane [1,2-c:4,3-c'] dipyrazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-02 | — | — | EP | disclosed |
| EP-0525129-A4 | SUBSTITUTED BENZIMIDAZOLES | — | 1993-03-24 | — | — | EP | disclosed |
| EP-0525129-A1 | SUBSTITUTED BENZIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-03 | — | — | EP | disclosed |
| EP-0276834-A1 | Cycloalkane [1,2-c:4,3-c'] dipyrazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4734429-A | Cycloalkane[1,2-c:4,3-c']dipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | disclosed |