Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.65 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.65 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA4 | P22748 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533291 | 0.91 | PLK1 (0.51) | PLK1CSNK2A1PLK3HTTSMN1; SMN2 | |
| SCHEMBL9533304 | 0.91 | PLK1 (0.51) | PLK1CSNK2A1PLK3HTTSMN1; SMN2 | |
| SCHEMBL1986758 | 0.80 | PLK1 (1.00) | PLK1CSNK2A1PLK3HTTSMN1; SMN2 | |
| SCHEMBL3142557 | 0.76 | PLK1 (0.93) | PLK1CSNK2A1PLK3HTTSMN1; SMN2 | |
| SCHEMBL9533936 | 0.74 | PLK1 (0.74) | PLK1CSNK2A1PLK3HTTSMN1; SMN2 | |
| SCHEMBL955853 | 0.72 | SMN1; SMN2 (0.57) | HTTSMN1; SMN2POLBL3MBTL1TP53 | |
| SCHEMBL9535827 | 0.71 | HTT (0.43) | PLK1CSNK2A1PLK3HTTSMN1; SMN2 | |
| SCHEMBL22980483 | 0.69 | PLK1 (0.79) | PLK1CSNK2A1PLK3HTTSMN1; SMN2 | |
| SCHEMBL3142596 | 0.68 | SMN1; SMN2 (0.52) | HTTSMN1; SMN2POLBL3MBTL1TP53 | |
| SCHEMBL9214131 | 0.68 | PLK1 (0.59) | PLK1CSNK2A1PLK3HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276834-B1 | Cycloalkane [1,2-c:4,3-c'] dipyrazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-02 | — | — | EP | disclosed |
| EP-0276834-A1 | Cycloalkane [1,2-c:4,3-c'] dipyrazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4734429-A | Cycloalkane[1,2-c:4,3-c']dipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | disclosed |