Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 7/20 | 0.49 |
| ▸ | METAP1 | P53582 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2919195 | 0.81 | MAPT (0.51) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL856747 | 0.78 | ACHE (0.56) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL490810 | 0.77 | MAPT (0.70) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL31460799 | 0.77 | MAPT (0.70) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL6117550 | 0.77 | MEN1 (0.48) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL3948845 | 0.76 | MAPT (0.56) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL30702212 | 0.76 | MAPT (0.56) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL5311960 | 0.75 | KMT2A (0.55) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL8319737 | 0.75 | ACHE (0.45) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL8112023 | 0.75 | KDM4E (0.34) | KDM4EMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347773-B1 | CONDENSED PYRAZOLE 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-04-28 | — | — | EP | disclosed |
| EP-0422051-A1 | CONDENSED PYRAZOLE 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012630-A1 | CONDENSED PYRAZOLE 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-12-28 | — | — | WO | disclosed |
| EP-0347773-A1 | Condensed Pyrazole 3-oxo-propanenitrile derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1989-12-27 | — | — | EP | disclosed |