Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | METAP1 | P53582 | 4/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319741 | 0.82 | MAPT (0.45) | ACHESMN1; SMN2NPC1RAB9AMETAP1 | |
| SCHEMBL8312673 | 0.81 | CYP11B1 (0.36) | SMN1; SMN2RAB9AMETAP1KDM4E | |
| SCHEMBL10947753 | 0.78 | ACHE (0.49) | ACHESMN1; SMN2NPC1RAB9AMETAP1 | |
| SCHEMBL10947764 | 0.78 | ACHE (0.49) | ACHESMN1; SMN2NPC1RAB9AMETAP1 | |
| Ethylene SCHEMBL9316053 | 0.75 | ACHE (0.46) | ACHESMN1; SMN2NPC1RAB9AMETAP1 | |
| SCHEMBL9533589 | 0.75 | KDM4E (0.49) | ACHESMN1; SMN2METAP1KDM4EMEN1 | |
| SCHEMBL8797208 | 0.72 | ACHE (0.49) | ACHESMN1; SMN2NPC1RAB9AMETAP1 | |
| SCHEMBL28871636 | 0.70 | MTNR1A (0.50) | MTNR1AMTNR1BMEN1KMT2AMAPT | |
| SCHEMBL28871634 | 0.70 | MTNR1A (0.50) | MTNR1AMTNR1BMEN1KMT2AMAPT | |
| SCHEMBL8304284 | 0.69 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922716-A | 5H-indeno 1,2-b!pyrazine-2,3-dione derivatives, their preparation and medicinal products containing them | RHONE-POULENC RORER S.A. (FR) | 1999-07-13 | — | — | US | disclosed |
| EP-0752988-B1 | 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE DERIVATIVES ANTAGONISTS OF AMPA AND NMDA RECEPTORS | RHONE POULENC RORER SA (FR) | 1999-05-26 | — | — | EP | disclosed |
| EP-0752988-A1 | 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995026342-A1 | 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1995-10-05 | — | — | WO | disclosed |