Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536660 | 0.83 | GPBAR1 (0.47) | MAPTALDH1A1 | |
| SCHEMBL9536417 | 0.83 | GPBAR1 (0.46) | ALDH1A1L3MBTL1 | |
| SCHEMBL9534838 | 0.81 | MAPT (0.56) | MAPTALDH1A1CYP2C19TP53TSHR | |
| SCHEMBL5243618 | 0.79 | HSD17B10 (0.59) | MAPTALDH1A1CYP2C19TP53HSD17B10 | |
| SCHEMBL27936754 | 0.79 | HSD17B10 (0.59) | MAPTALDH1A1CYP2C19TP53HTT | |
| SCHEMBL9533615 | 0.79 | HSD17B10 (0.59) | MAPTALDH1A1CYP2C19TP53HSD17B10 | |
| SCHEMBL9537484 | 0.77 | LMNA (0.52) | MAPTALDH1A1TSHRHTTHSD17B10 | |
| SCHEMBL9535039 | 0.76 | KMT2A (0.67) | MAPTALDH1A1TP53TSHRHTT | |
| SCHEMBL9532664 | 0.74 | HSD17B10 (0.53) | MAPTALDH1A1CYP2C19TP53TSHR | |
| SCHEMBL9534026 | 0.73 | MAPT (0.57) | MAPTCYP2C19TP53HTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573883-A1 | Utilization of 3 substituted aryl-5-alkyl-isoxazole-4-carboxylic acid derivatives against endoparasites new 3-substituted aryl-5-alkyl-isoxazole-4-carboxylic acid derivatives and process for their preparation | BAYER AG (DE) | 1993-12-15 | — | — | EP | disclosed |