Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 6/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 6/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535344 | 0.80 | ELANE (0.43) | TNKS2PARP2ALDH1A1KDM4EAPP | |
| SCHEMBL9533817 | 0.77 | TNKS (0.43) | TNKSTNKS2PARP2ALDH1A1KDM4E | |
| SCHEMBL9534241 | 0.76 | PKM (0.50) | TNKSTNKS2PARP2ALDH1A1KDM4E | |
| SCHEMBL10695492 | 0.73 | PARP1 (0.39) | TNKSTNKS2PARP2ALDH1A1KDM4E | |
| SCHEMBL10695759 | 0.73 | CYP1A1 (0.43) | TNKSTNKS2PARP2ALDH1A1KDM4E | |
| SCHEMBL9770629 | 0.71 | TNKS (0.42) | TNKSTNKS2PARP2ALDH1A1KDM4E | |
| SCHEMBL9536686 | 0.70 | KDM4E (0.59) | TNKSTNKS2PARP2ALDH1A1KDM4E | |
| SCHEMBL10996994 | 0.70 | TP53 (0.41) | ALDH1A1KDM4ECYP1A2APPMAPT | |
| SCHEMBL10695623 | 0.69 | KDM4E (0.51) | TNKSTNKS2PARP2ALDH1A1KDM4E | |
| SCHEMBL9534683 | 0.68 | PIK3R2 (0.37) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0263523-B1 | Process for the preparation of thiazolo [2,3-b] quinazolones | BASF AG (DE) | 1993-12-29 | — | — | EP | disclosed |
| EP-0263523-A2 | Process for the preparation of thiazolo [2,3-b] quinazolones | BASF Aktiengesellschaft (DE) | 1988-04-13 | — | — | EP | disclosed |