Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP46A1 | Q9Y6A2 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SCN1A | P35498 | 2/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2117 | 0.86 | SCN1A (0.45) | TDP1L3MBTL1KDM4EMAPK1SCN1A | |
| SCHEMBL2302 | 0.84 | SCN1A (0.51) | TDP1L3MBTL1KDM4EMAPK1SCN1A | |
| SCHEMBL14901089 | 0.83 | KDM4E (0.61) | CYP46A1TDP1L3MBTL1KDM4EMAPK1 | |
| SCHEMBL10441552 | 0.83 | TSHR (0.59) | CYP46A1TDP1L3MBTL1KDM4EMAPK1 | |
| SCHEMBL31290645 | 0.78 | CYP46A1 (0.56) | CYP46A1TDP1L3MBTL1KDM4EMAPK1 | |
| SCHEMBL6215461 | 0.78 | NPC1 (0.41) | L3MBTL1KDM4EMAPK1MEN1KMT2A | |
| SCHEMBL1775361 | 0.77 | CYP46A1 (0.72) | CYP46A1L3MBTL1KDM4EHDAC7PTGDR2 | |
| SCHEMBL6164950 | 0.75 | ALDH1A1 (0.43) | TDP1L3MBTL1KDM4EMAPK1MEN1 | |
| SCHEMBL2127 | 0.75 | SCN1A (0.50) | TDP1L3MBTL1MAPK1SCN1ASCN2A | |
| SCHEMBL12554597 | 0.74 | KDM4E (0.41) | TDP1L3MBTL1KDM4EMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572455-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | Astra Pharmaceuticals Limited (GB) | 1993-12-08 | — | — | EP | disclosed |
| WO-1992014714-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | FISONS PLC (GB) | 1992-09-03 | — | — | WO | disclosed |
| EP-0500297-A1 | Substituted pyridinones and pyrimidinones as angiotensin II antagonists | FISONS plc (GB) | 1992-08-26 | — | — | EP | disclosed |