Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 2/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533684 | 0.86 | CYP46A1 (0.49) | SCN1ASCN2ASCN3AALDH1A1TDP1 | |
| SCHEMBL2127 | 0.84 | SCN1A (0.50) | SCN1ASCN2ASCN3ALTB4R2ALDH1A1 | |
| SCHEMBL2116 | 0.77 | FOLH1 (0.45) | SCN1ASCN2ASCN3AFOLH1LTB4R | |
| SCHEMBL3202 | 0.77 | SCN1A (0.51) | SCN1ASCN2ASCN3AALDH1A1TSHR | |
| SCHEMBL3431159 | 0.76 | FOLH1 (0.53) | SCN1ASCN2ASCN3AFOLH1LTB4R | |
| SCHEMBL2302 | 0.75 | SCN1A (0.51) | SCN1ASCN2ASCN3AALDH1A1TSHR | |
| SCHEMBL9407400 | 0.74 | FOLH1 (0.75) | FOLH1LTB4RLTB4R2CA12CA2 | |
| SCHEMBL3234150 | 0.72 | CYP4F2 (0.62) | SCN1ASCN2ASCN3AFOLH1ALDH1A1 | |
| SCHEMBL1615 | 0.72 | SCN1A (0.51) | SCN1ASCN2ASCN3AALDH1A1TSHR | |
| SCHEMBL25054408 | 0.70 | L3MBTL1 (0.52) | ALDH1A1TSHRTDP1L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |