Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 2/20 | 0.51 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.51 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2127 | 0.88 | SCN1A (0.50) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL1615 | 0.85 | SCN1A (0.51) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL3202 | 0.85 | SCN1A (0.51) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL9533684 | 0.84 | CYP46A1 (0.49) | SCN1ASCN2ASCN3AALDH1A1L3MBTL1 | |
| SCHEMBL3230316 | 0.82 | TSHR (0.65) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL29500171 | 0.82 | TSHR (0.65) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL3633116 | 0.82 | TSHR (0.67) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL29500191 | 0.82 | TSHR (0.67) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL15907643 | 0.80 | ALDH1A1 (0.68) | SCN1ASCN2ASCN3AALDH1A1TSHR | |
| SCHEMBL25054408 | 0.79 | L3MBTL1 (0.52) | ALDH1A1TSHRL3MBTL1TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |