Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | GLP1R | P43220 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11207252 | 0.86 | ALDH1A1 (0.33) | ALDH1A1CYP3A4NQO2THRBACHE | |
| SCHEMBL9534242 | 0.77 | MEN1 (0.42) | ALDH1A1CYP3A4ACHECASP6MAPT | |
| SCHEMBL11215259 | 0.76 | THRB (0.46) | ALDH1A1CYP3A4NQO2THRBACHE | |
| 2,3-Dihydroxy-6,7-Dichloroquinoxaline SCHEMBL1259521 | 0.73 | MMP1 (0.50) | ALDH1A1CYP3A4NQO2MMP1MMP2 | |
| SCHEMBL6108034 | 0.72 | GAA (0.48) | ALDH1A1CYP3A4NQO2THRBACHE | |
| SCHEMBL11217567 | 0.71 | NQO2 (0.33) | NQO2 | |
| SCHEMBL9534757 | 0.71 | MMP14 (0.33) | ALDH1A1CYP3A4NQO2CASP6MAPT | |
| SCHEMBL9532920 | 0.69 | MAPT (0.38) | ALDH1A1NQO2THRBCASP6MAPT | |
| SCHEMBL9533866 | 0.69 | NQO2 (0.35) | NQO2MAPT | |
| SCHEMBL9534423 | 0.67 | MAPT (0.39) | THRBACHEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0348872-B1 | FUSED DIHYDROXYQUINOXALINES AND THEIR USE AS GLUTAMATE ANTAGONISTS | NOVO NORDISK A/S (DK) | 1993-09-29 | — | — | EP | disclosed |
| US-5109001-A | Treating hyperactivity of excitatory neurotransmitters | NOVO NORDISK A/S (DK) | 1992-04-28 | — | — | US | disclosed |
| US-5079250-A | TRICYCLIC HETEROCYCLIC DIOLS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-01-07 | — | — | US | disclosed |
| US-5075306-A | Nervous system, psychological disorders | NOVO NORDISK A/S (DK) | 1991-12-24 | — | — | US | disclosed |
| US-5057516-A | Nervous system disorders | NOVO NORDISK A/S (DK) | 1991-10-15 | — | — | US | disclosed |
| US-4977155-A | Nervous system disorders | A/S FERROSAN (DK) | 1990-12-11 | — | — | US | disclosed |
| EP-0348872-A1 | Fused dihydroxyquinoxalines and their use as glutamate antagonists | NOVO NORDISK A/S (DK) | 1990-01-03 | — | — | EP | disclosed |