Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 5/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9776624 | 0.99 | MTNR1A (0.51) | MTNR1AMTNR1BHTR1ADRD2DRD4 | |
| SCHEMBL9537304 | 0.86 | MTNR1A (0.58) | MTNR1AMTNR1BHTR1ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9776461 | 0.85 | MTNR1A (0.57) | MTNR1AMTNR1BHTR1ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9532136 | 0.84 | MTNR1A (0.48) | MTNR1AMTNR1BHTR1ADRD2DRD4 | |
| SCHEMBL9536375 | 0.79 | DRD2 (0.42) | MTNR1AMTNR1BHTR1ADRD2DRD4 | |
| SCHEMBL9532979 | 0.77 | MTNR1A (0.64) | MTNR1AMTNR1BDRD2DRD4DRD3 | |
| SCHEMBL9537025 | 0.76 | MTNR1A (0.58) | MTNR1AMTNR1B | |
| SCHEMBL10340388 | 0.75 | MTNR1A (0.67) | MTNR1AMTNR1BDRD2DRD4DRD3 | |
| SCHEMBL9532235 | 0.75 | MTNR1A (0.53) | MTNR1AMTNR1BHTR1ADRD2DRD3 | |
| SCHEMBL9533770 | 0.75 | DRD2 (0.53) | MTNR1AMTNR1BHTR1ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021438-A | Having affinity for 5-hydroxytryptamine receptors; treating central nervous system and cardiovascular disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1991-06-04 | — | — | US | claimed |
| EP-0332968-B1 | 1,3,4,5-Tetrahydrobenz[c,d]indoles | BAYER AG (DE) | 1993-06-02 | — | — | EP | disclosed |
| EP-0332968-A1 | 1,3,4,5-Tetrahydrobenz[c,d]indoles | BAYER AG (DE) | 1989-09-20 | — | — | EP | disclosed |