Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 18/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 17/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8624777 | 0.77 | TBXAS1 (0.36) | HRH4HRH3TP53CYP1A2CYP3A4 | |
| SCHEMBL9534159 | 0.74 | HRH4 (1.00) | HRH4HRH3TP53CYP1A2CYP3A4 | |
| Clobenpropit SCHEMBL49050 | 0.72 | HRH4 (1.00) | HRH4HRH3TP53CYP1A2CYP3A4 | |
| Iodophenpropit SCHEMBL22651297 | 0.71 | HRH4 (1.00) | HRH4HRH3TP53CYP1A2CYP3A4 | |
| Iodophenpropit SCHEMBL114508 | 0.71 | HRH4 (1.00) | HRH4HRH3TP53CYP1A2CYP3A4 | |
| Iodophenpropit SCHEMBL30632137 | 0.70 | HRH4 (1.00) | HRH4HRH3TP53CYP1A2CYP3A4 | |
| SCHEMBL29511085 | 0.68 | HRH2 (0.72) | HRH4HRH3 | |
| SCHEMBL14415981 | 0.66 | HRH3 (0.64) | HRH4HRH3 | |
| SCHEMBL18325628 | 0.66 | HRH4 (1.00) | HRH4HRH3 | |
| SCHEMBL4680197 | 0.64 | HRH3 (0.51) | HRH4HRH3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573542-A1 | IMIDAZOLE-DERIVATIVES HAVING AGONISTIC OR ANTAGONISTIC ACTIVITY ON THE HISTAMINE H 3?-RECEPTOR. | SEED CAPITAL INVESTMENTS (NL) | 1993-12-15 | — | — | EP | claimed |