Iodophenpropit

Iodophenpropit

SCHEMBL22651297

N/C(=N/CCc1ccc(I)cc1)SCCCc1cnc[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 20/20 1.00
TP53 P04637 2/20 1.00
CYP1A2 P05177 2/20 1.00
CYP3A4 P08684 2/20 1.00
MEN1 O00255 1/20 1.00
TSHR P16473 1/20 1.00
KMT2A Q03164 1/20 1.00
HRH3 Q9Y5N1 19/20 0.98
CYP2D6 P10635 1/20 0.64
CYP2C9 P11712 1/20 0.64
CYP2C19 P33261 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Iodophenpropit SCHEMBL114508 1.00 HRH4 (1.00) HRH4TP53CYP1A2CYP3A4MEN1
Iodophenpropit SCHEMBL30632137 0.99 HRH4 (1.00) HRH4TP53CYP1A2CYP3A4MEN1
SCHEMBL26687384 0.81 HRH4 (0.69) HRH4TP53CYP1A2CYP3A4MEN1
Clobenpropit SCHEMBL49050 0.78 HRH4 (1.00) HRH4TP53CYP1A2CYP3A4MEN1
SCHEMBL9534159 0.78 HRH4 (1.00) HRH4TP53CYP1A2CYP3A4HRH3
SCHEMBL8805366 0.77 HRH4 (0.63) HRH4TP53CYP1A2CYP3A4MEN1
SCHEMBL9533886 0.71 HRH4 (0.58) HRH4TP53CYP1A2CYP3A4MEN1
SCHEMBL7859117 0.67 HRH4 (1.00) HRH4HRH3
SCHEMBL8621926 0.65 HRH3 (0.60) HRH4TP53CYP1A2CYP3A4MEN1
Clobenpropit SCHEMBL19733457 0.63 HRH4 (0.65) HRH4TP53CYP1A2CYP3A4HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230346879-A1 COMPOSITIONS AND METHODS FOR COMBINATORIAL DRUG DISCOVERY IN NANOLITER DROPLETS MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2023-11-02 US claimed
US-11564970-B2 Compositions and methods for combinatorial drug discovery in nanoliter droplets THE BROAD INSTITUTE, INC. (US) 2023-01-31 US claimed
US-20250367232-A1 HALOGEN TREATMENT OF HEART ATTACK AND ISCHEMIC INJURY HUTCHINSON FRED CANCER RES (US) 2025-12-04 US disclosed
US-20250078957-A1 Unsupervised Machine Learning Methods AMPEL BIOSOLUTIONS LLC (US) 2025-03-06 US disclosed
US-20250022541-A1 Unsupervised Machine Learning Methods AMPEL BIOSOLUTIONS LLC (US) 2025-01-16 US disclosed
US-20240428948-A1 Unsupervised Machine Learning Methods AMPEL BIOSOLUTIONS LLC (US) 2024-12-26 US disclosed
EP-4479973-A1 UNSUPERVISED MACHINE LEARNING METHODS Ampel Biosolutions, LLC (US) 2024-12-25 EP disclosed
US-12016880-B2 Halogen treatment of heart attack and ischemic injury FRED HUTCHINSON CANCER CENTER (US) 2024-06-25 US disclosed
EP-3104939-B1 TREATMENT OF HEART ATTACK AND ISCHEMIC INJURY WITH SODIUM IODIDE FRED HUTCHINSON CANCER CENTER (US) 2024-05-01 EP disclosed
US-20240100018-A1 COMPOUNDS FOR THE TREATMENT OF A DISEASE OR DISORDER, METHODS FOR IDENTIFYING SAID COMPOUNDS CEDARS-SINAI MEDICAL CENTER 2024-03-28 US disclosed
US-20230346879-A1 COMPOSITIONS AND METHODS FOR COMBINATORIAL DRUG DISCOVERY IN NANOLITER DROPLETS MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2023-11-02 US disclosed
WO-2023158713-A1 UNSUPERVISED MACHINE LEARNING METHODS AMPEL BIOSOLUTIONS, LLC (US) 2023-08-24 WO disclosed
US-11564970-B2 Compositions and methods for combinatorial drug discovery in nanoliter droplets THE BROAD INSTITUTE, INC. (US) 2023-01-31 US disclosed
US-11564970-B2 Compositions and methods for combinatorial drug discovery in nanoliter droplets THE BROAD INSTITUTE, INC. (US) 2023-01-31 US disclosed
US-20220387483-A1 USE OF IODIDE COMPOUNDS FOR THE TREATMENT AND PREVENTION OF CHEMOTHERAPY-ASSOCIATED CACHEXIA AND CARDIOTOXICITY FARADAY PHARMACEUTICALS INC (US) 2022-12-08 US disclosed
US-20220313730-A1 HALOGEN TREATMENT OF HEART ATTACK AND ISCHEMIC INJURY FRED HUTCHINSON CANCER CENTER 2022-10-06 US disclosed
EP-4054593-A1 USE OF IODIDE COMPOUNDS FOR THE TREATMENT AND PREVENTION OF CHEMOTHERAPY-ASSOCIATED CACHEXIA AND CARDIOTOXICITY Faraday Pharmaceuticals, Inc. (US) 2022-09-14 EP disclosed
US-20200353033-A1 COMPOSITIONS AND METHODS FOR COMBINATORIAL DRUG DISCOVERY IN NANOLITER DROPLETS THE BROAD INSTITUTE, INC. (US) 2020-11-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230346879-A1 COMPOSITIONS AND METHODS FOR COMBINATORIAL DRUG DISCOVERY IN NANOLITER DROPLETS RAB5IF, CLTB, TBK1 HRH4 4196/4885TP53 2153/4885CYP1A2 4441/4885
US-20200353033-A1 COMPOSITIONS AND METHODS FOR COMBINATORIAL DRUG DISCOVERY IN NANOLITER DROPLETS RAB5IF, CLTB, TBK1 HRH4 4196/4885TP53 2153/4885CYP1A2 4441/4885
US-11564970-B2 Compositions and methods for combinatorial drug discovery in nanoliter droplets RAB5IF, LIPA, CLTB HRH4 3614/4885TP53 3037/4885CYP1A2 4134/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.