Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | EDNRB | P24530 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9532111 | 0.94 | AGTR2 (0.42) | AGTR2EDNRBEDNRA | |
| SCHEMBL9592563 | 0.81 | EDNRB (0.49) | AGTR2EDNRBEDNRA | |
| SCHEMBL9531226 | 0.80 | AGTR1 (0.35) | AGTR2AGTR1 | |
| SCHEMBL9591738 | 0.79 | GSK3B (0.50) | PTPN1AGTR2 | |
| SCHEMBL27381949 | 0.78 | GPR84 (0.51) | AGTR2AGTR1 | |
| SCHEMBL9591188 | 0.77 | AGTR2 (0.47) | AGTR2AGTR1 | |
| SCHEMBL9591325 | 0.77 | AGTR2 (0.53) | AGTR2EDNRBEDNRA | |
| SCHEMBL9591814 | 0.75 | PDE4A (0.47) | AGTR2 | |
| SCHEMBL4275342 | 0.75 | PTPN1 (0.64) | PTPN1 | |
| SCHEMBL9535397 | 0.75 | AGTR1 (0.70) | AGTR2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572455-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | Astra Pharmaceuticals Limited (GB) | 1993-12-08 | — | — | EP | claimed |
| WO-1992014714-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | FISONS PLC (GB) | 1992-09-03 | — | — | WO | claimed |
| EP-0500297-A1 | Substituted pyridinones and pyrimidinones as angiotensin II antagonists | FISONS plc (GB) | 1992-08-26 | — | — | EP | claimed |
| EP-0572455-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | Astra Pharmaceuticals Limited (GB) | 1993-12-08 | — | — | EP | disclosed |
| WO-1992014714-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | FISONS PLC (GB) | 1992-09-03 | — | — | WO | disclosed |
| EP-0500297-A1 | Substituted pyridinones and pyrimidinones as angiotensin II antagonists | FISONS plc (GB) | 1992-08-26 | — | — | EP | disclosed |