Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | MARK3 | P27448 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 2/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9218737 | 0.73 | DRD4 (0.48) | AURKAPIM1MAPTDRD4DRD2 | |
| SCHEMBL9534036 | 0.73 | CSNK2A1 (0.35) | AURKACHEK2CDK1PIM1FGFR1 | |
| SCHEMBL9537353 | 0.62 | CCNA2 (0.39) | CDK2CSNK2A1 | |
| SCHEMBL12304120 | 0.56 | ADORA2A (0.42) | — | |
| SCHEMBL12304116 | 0.54 | PARP1 (0.45) | — | |
| SCHEMBL9222650 | 0.53 | DRD2 (0.53) | CSNK2A1MAPTDRD4DRD2 | |
| SCHEMBL9538656 | 0.52 | PLK1 (0.39) | CSNK2A1DRD4DRD2 | |
| SCHEMBL9534890 | 0.52 | MMP12 (0.40) | CSNK2A1 | |
| SCHEMBL9219954 | 0.51 | DRD4 (0.55) | AURKAPIM1MAPTDRD4DRD2 | |
| SCHEMBL19297278 | 0.51 | PARP1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276835-B1 | PYRAZOLOTHIOPYRANOPYRAZOLES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0276835-A1 | Pyrazolothiopyranopyrazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4734431-A | Thiopyranodipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | disclosed |