Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534888 | 0.87 | PRMT5 (0.41) | ADORA1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9533257 | 0.86 | ADRA2A (0.57) | ADORA1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9534803 | 0.85 | KAT2B (0.40) | ADORA1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9535094 | 0.80 | ALDH1A1 (0.44) | ADORA1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9376562 | 0.74 | ADRA1D (0.50) | ADORA1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9535318 | 0.74 | ADRA1A (0.39) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL9533999 | 0.71 | ALDH1A1 (0.45) | ADORA1ADRA2AADRA1AALDH1A1L3MBTL1 | |
| SCHEMBL9533309 | 0.71 | ADRA1D (0.68) | ADORA1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9535724 | 0.71 | ADRA2A (0.61) | ADORA1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9534502 | 0.67 | ADRA2A (0.56) | ADORA1ADRA2AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384677-B1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1993-12-01 | — | — | EP | disclosed |
| US-4981848-A | CARDIOVASCULAR, HYPOTENSIVE, ANTIDEPRESSANT | SMITHKLINE BEECHAM CORPORATION (US) | 1991-01-01 | — | — | US | disclosed |
| EP-0384677-A1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-08-29 | — | — | EP | disclosed |