Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164696 | 0.80 | HTT (0.61) | HTTLMNAMAPTPLK1CSNK2A1 | |
| SCHEMBL955853 | 0.72 | SMN1; SMN2 (0.57) | HTTL3MBTL1TP53POLBSMN1; SMN2 | |
| SCHEMBL9534422 | 0.71 | PLK1 (0.65) | HTTL3MBTL1TP53POLBSMN1; SMN2 | |
| SCHEMBL3142596 | 0.68 | SMN1; SMN2 (0.52) | HTTL3MBTL1TP53POLBSMN1; SMN2 | |
| SCHEMBL21635879 | 0.66 | SMN1; SMN2 (0.50) | HTTL3MBTL1TP53POLBSMN1; SMN2 | |
| SCHEMBL21678821 | 0.65 | HTT (0.38) | HTTPARP1 | |
| SCHEMBL6837311 | 0.64 | MAP1LC3B (0.47) | HTTL3MBTL1TP53POLBSMN1; SMN2 | |
| SCHEMBL6166619 | 0.63 | HTT (0.42) | HTTLMNAPLK1CSNK2A1PLK3 | |
| SCHEMBL9533291 | 0.62 | PLK1 (0.51) | HTTL3MBTL1POLBSMN1; SMN2MAPT | |
| SCHEMBL9533304 | 0.62 | PLK1 (0.51) | HTTL3MBTL1POLBSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276834-B1 | Cycloalkane [1,2-c:4,3-c'] dipyrazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-02 | — | — | EP | disclosed |
| EP-0276834-A1 | Cycloalkane [1,2-c:4,3-c'] dipyrazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4734429-A | Cycloalkane[1,2-c:4,3-c']dipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | disclosed |