Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | LAP3 | P28838 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533567 | 0.87 | MEN1 (0.46) | MEN1KMT2AALOX15LTA4HLAP3 | |
| SCHEMBL14823645 | 0.84 | ALOX5 (0.46) | MEN1KMT2AALOX15MAPTL3MBTL1 | |
| SCHEMBL9533458 | 0.82 | FFAR1 (0.56) | FFAR1PPARGPPARA | |
| SCHEMBL9533468 | 0.81 | MEN1 (0.41) | MEN1KMT2AALOX15FFAR1ITGB3 | |
| SCHEMBL9533108 | 0.79 | HPGD (0.57) | PPARG | |
| SCHEMBL9533148 | 0.79 | HPGD (0.57) | PPARG | |
| SCHEMBL9533152 | 0.79 | HPGD (0.44) | MEN1KMT2APPARG | |
| SCHEMBL20380518 | 0.75 | RAB9A (0.54) | LTA4HLAP3MAPTL3MBTL1CCR6 | |
| SCHEMBL8976312 | 0.74 | ALOX15 (0.52) | MEN1KMT2AALOX15ALOX5BACE1 | |
| SCHEMBL4583955 | 0.73 | KMT2A (0.54) | MEN1KMT2AALOX15MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555251-A1 | THIAZOLIDINE DIONE DERIVATIVES | BEECHAM GROUP plc (GB) | 1993-08-18 | — | — | EP | disclosed |
| WO-1992007838-A1 | THIAZOLIDINE DIONE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1992-05-14 | — | — | WO | disclosed |