Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534763 | 1.00 | THRB (0.39) | THRBLMNAMAPTAOC3KMT2A | |
| SCHEMBL10370092 | 0.74 | MAPT (0.43) | THRBLMNAMAPTKMT2AMEN1 | |
| SCHEMBL10370093 | 0.74 | MAPT (0.43) | THRBLMNAMAPTKMT2AMEN1 | |
| SCHEMBL15332519 | 0.69 | AOC3 (0.42) | MAPTAOC3KMT2AMEN1L3MBTL1 | |
| SCHEMBL9535687 | 0.69 | LMNA (0.40) | LMNAMAPTAOC3KMT2AMEN1 | |
| SCHEMBL9535682 | 0.69 | LMNA (0.40) | LMNAMAPTAOC3KMT2AMEN1 | |
| SCHEMBL3791186 | 0.66 | ALDH1A1 (0.40) | LMNAMAPTAOC3KMT2AMEN1 | |
| SCHEMBL474385 | 0.65 | KMT2A (0.49) | LMNAMAPTAOC3KMT2AMEN1 | |
| SCHEMBL1029816 | 0.65 | KMT2A (0.43) | LMNAMAPTAOC3KMT2AMEN1 | |
| SCHEMBL2556702 | 0.63 | AOC3 (0.36) | MAPTAOC3KMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243311-B1 | Pyrido[2,3-d]pyrimidine derivatives | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1993-06-09 | — | — | EP | disclosed |
| US-4808587-A | ANTIALLEGENS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1989-02-28 | — | — | US | disclosed |
| EP-0243311-A2 | Pyrido[2,3-d]pyrimidine derivatives | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1987-10-28 | — | — | EP | disclosed |