Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | CTRC | Q99895 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536313 | 0.88 | DHODH (0.42) | MEN1KMT2APDCD1CD274SLC6A2 | |
| SCHEMBL20718975 | 0.85 | CD274 (0.39) | MEN1KMT2APDCD1CD274NPC1 | |
| SCHEMBL9534914 | 0.84 | SLC6A2 (0.47) | MEN1KMT2APDCD1CD274SLC6A2 | |
| SCHEMBL20719469 | 0.83 | MEN1 (0.44) | MEN1KMT2APDCD1CD274JAK2 | |
| SCHEMBL20719845 | 0.81 | SLC6A2 (0.49) | MEN1KMT2APDCD1CD274SLC6A2 | |
| SCHEMBL9538604 | 0.81 | CD274 (0.45) | MEN1KMT2APDCD1CD274KDM4E | |
| SCHEMBL20719844 | 0.79 | ALDH1A1 (0.53) | MEN1KMT2APDCD1CD274JAK2 | |
| SCHEMBL9533834 | 0.79 | ALDH1A1 (0.52) | PDCD1CD274KDM4EALDH1A1HPGD | |
| SCHEMBL9534377 | 0.78 | MEN1 (0.42) | MEN1KMT2ACD274JAK2JAK3 | |
| SCHEMBL9534841 | 0.77 | MEN1 (0.41) | MEN1KMT2ACD274JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532531-A1 | PHENOL AND PYRIDINOL DERIVATIVES AS PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |
| WO-1991017987-A1 | PHENOL AND PYRIDINOL DERIVATIVES AS PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-11-28 | — | — | WO | disclosed |