Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 12/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TACR2 | P21452 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9266568 | 0.83 | HRH1 (0.66) | TP53HRH1CYP2D6KCNH2ALDH1A1 | |
| SCHEMBL9535375 | 0.82 | HRH1 (0.55) | HRH1KCNH2ALDH1A1SMN1; SMN2CHRM1 | |
| SCHEMBL6995354 | 0.82 | LMNA (0.71) | TP53HRH1CYP2D6KCNH2ALDH1A1 | |
| SCHEMBL8138397 | 0.81 | ALDH1A1 (0.43) | ALDH1A1GAAL3MBTL1SMN1; SMN2CHRM1 | |
| SCHEMBL9699718 | 0.81 | HRH1 (0.56) | TP53HRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL9699714 | 0.81 | ALDH1A1 (0.53) | TP53HRH1CYP2D6KCNH2ALDH1A1 | |
| SCHEMBL8566268 | 0.81 | ALDH1A1 (0.42) | HRH1ALDH1A1L3MBTL1SMN1; SMN2CHRM1 | |
| SCHEMBL9541863 | 0.81 | ALDH1A1 (0.51) | TP53HRH1CYP2D6KCNH2ALDH1A1 | |
| SCHEMBL9536075 | 0.81 | HRH1 (0.62) | TP53HRH1CYP2D6KCNH2LMNA | |
| SCHEMBL9629294 | 0.79 | LMNA (0.67) | TP53HRH1CYP2D6KCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |