Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 1/20 | 0.31 |
| ▸ | CCR6 | P51684 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.31 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531257 | 0.89 | CYP11B2 (0.33) | CYP11B2ALDH1A1LMNAHPGDL3MBTL1 | |
| SCHEMBL10390416 | 0.84 | DAPK3 (0.36) | CYP11B2ALDH1A1LMNAHPGDL3MBTL1 | |
| SCHEMBL9533729 | 0.80 | IDO1 (0.34) | CYP11B2CCR6USP2HSD11B1TSHR | |
| SCHEMBL10516865 | 0.74 | CYP11B2 (0.32) | CYP11B2ALDH1A1LMNATSHR | |
| SCHEMBL2819775 | 0.73 | CYP11B2 (0.45) | CYP11B2CCR6KMT2A | |
| SCHEMBL2819780 | 0.73 | CYP11B2 (0.45) | CYP11B2CCR6KMT2A | |
| SCHEMBL2822367 | 0.73 | CYP11B2 (0.45) | CYP11B2CCR6KMT2A | |
| SCHEMBL10389944 | 0.73 | DAPK3 (0.37) | CYP11B2ALDH1A1LMNAHPGDL3MBTL1 | |
| SCHEMBL10596279 | 0.71 | CYP11B2 (0.35) | CYP11B2ACE | |
| SCHEMBL10648754 | 0.69 | CYP11B2 (0.41) | CYP11B2ALDH1A1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0314852-B1 | Process for the preparation of 1-substituted imidazole-carbonic acid and derivatives | CIBA GEIGY AG (CH) | 1993-11-18 | — | — | EP | disclosed |
| EP-0288196-B1 | Sulfonyldecahydro-8H-isoquino[2,1-g][1,6]naphthyridines, optical isomers thereof and related compounds | SYNTEX (U.S.A.) INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| US-5229387-A | Cardiovascular disorders, alpha2-adenoreceptor antagonist or hydroxytryptamine receivers as hypotensive agents | SYNTEX (U.S.A.) INC. (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0524004-A1 | Decahydro-8H-isoquino[2,1-g][1,6]naphthyridine and decahydrobenzo[a]pyrrolo[2,3-e]quinolizine derivatives | SYNTEX (U.S.A.) INC. (US) | 1993-01-20 | — | — | EP | disclosed |
| US-4956365-A | ANTIDEPRESSANTS, ANTIANXIETY AGENTS, ANTICOAGULANTS, ANTIDIABETIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1990-09-11 | — | — | US | disclosed |
| US-4886798-A | Optical isomers of sulfonyldecahydro-8H-isoquino-(2,1-G)(1,6) naphthyridines and related compounds useful as α2 -blockers | SYNTEX (U.S.A.) INC. (US) | 1989-12-12 | — | — | US | disclosed |
| EP-0314852-A2 | Process for the preparation of 1-substituted imidazole-carbonic acid and derivatives | CIBA-GEIGY AG (CH) | 1989-05-10 | — | — | EP | disclosed |