Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537012 | 1.00 | GAA (0.40) | GAAHPGDLMNAMEN1KMT2A | |
| SCHEMBL9535682 | 0.75 | LMNA (0.40) | LMNAMEN1KMT2AMAPT | |
| SCHEMBL9535687 | 0.75 | LMNA (0.40) | LMNAMEN1KMT2AMAPT | |
| SCHEMBL10370092 | 0.70 | MAPT (0.43) | GAAHPGDLMNAMEN1KMT2A | |
| SCHEMBL10370093 | 0.70 | MAPT (0.43) | GAAHPGDLMNAMEN1KMT2A | |
| SCHEMBL2760401 | 0.67 | KDM4E (0.44) | LMNAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL479900 | 0.66 | KDM4E (0.51) | GAAHPGDLMNAMEN1KMT2A | |
| SCHEMBL3798203 | 0.66 | RXFP1 (0.41) | GAALMNAMEN1KMT2AKDM4E | |
| SCHEMBL5416093 | 0.64 | ALDH1A1 (0.37) | GAAHPGDMEN1KMT2AKDM4E | |
| SCHEMBL8328828 | 0.63 | AOC3 (0.45) | GAAHPGDLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276835-B1 | PYRAZOLOTHIOPYRANOPYRAZOLES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-03-17 | — | — | EP | claimed |
| EP-0244352-B1 | Pyrido[4,3-d]pyrimidine derivatives | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1993-03-31 | — | — | EP | disclosed |
| US-4808618-A | ANTIALLERGENS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1989-02-28 | — | — | US | disclosed |
| EP-0244352-A2 | Pyrido[4,3-d]pyrimidine derivatives | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1987-11-04 | — | — | EP | disclosed |