Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RHEB | Q15382 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 2/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MLNR | O43193 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL11383873 | 0.86 | MTNR1A (0.45) | SRD5A2ALDH1A1DHFRGLAMTNR1A | |
| SCHEMBL9587713 | 0.85 | ALDH1A1 (0.43) | ALDH1A1DHFRGLAMTNR1AMTNR1B | |
| SCHEMBL11457360 | 0.85 | RHEB (0.51) | SRD5A2ALDH1A1DHFRGLAMTNR1A | |
| SCHEMBL5585050 | 0.83 | SRD5A2 (0.62) | SRD5A2ALDH1A1DHFRGLATP53 | |
| SCHEMBL5585048 | 0.83 | SRD5A2 (0.62) | SRD5A2ALDH1A1DHFRGLATP53 | |
| SCHEMBL9539022 | 0.83 | ALDH1A1 (0.49) | SRD5A2ALDH1A1DHFRGLAMTNR1A | |
| SCHEMBL11449804 | 0.81 | ALDH1A1 (0.47) | SRD5A2ALDH1A1DHFRGLAMTNR1A | |
| SCHEMBL11449730 | 0.80 | VDR (0.40) | SRD5A2ALDH1A1DHFRGLAMTNR1A | |
| SCHEMBL5761452 | 0.80 | SRD5A2 (0.48) | SRD5A2ALDH1A1DHFRGLATP53 | |
| SCHEMBL4385990 | 0.80 | SRD5A2 (0.48) | SRD5A2ALDH1A1DHFRGLATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375560-B1 | ARYLOXYPROPANOLAMINOTETRALINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ELF SANOFI (FR) | 1993-05-12 | — | — | EP | disclosed |
| EP-0375560-A1 | Aryloxypropanolaminotetralines, process for their preparation and pharmaceutical compositions containing same | ELF SANOFI (FR) | 1990-06-27 | — | — | EP | disclosed |