Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537518 | 0.92 | ALDH1A1 (0.36) | ALDH1A1HPGDOPRM1EPHX2HRH3 | |
| SCHEMBL9535584 | 0.90 | SMN1; SMN2 (0.38) | DPP4KMT2A | |
| SCHEMBL9536573 | 0.85 | MEN1 (0.43) | HPGDOPRM1EPHX2MEN1KMT2A | |
| SCHEMBL9535279 | 0.82 | PLA2G1B (0.36) | ALDH1A1 | |
| SCHEMBL9536801 | 0.81 | POLB (0.39) | OPRM1 | |
| SCHEMBL9727314 | 0.81 | DPP4 (0.49) | ALDH1A1HPGDOPRM1CYP3A4CYP2D6 | |
| SCHEMBL9538045 | 0.79 | DRD1 (0.48) | ALDH1A1HTTDPP4MEN1KMT2A | |
| SCHEMBL9538148 | 0.78 | KMT2A (0.42) | ALDH1A1OPRM1MEN1KMT2A | |
| SCHEMBL9534996 | 0.78 | OPRK1 (0.40) | HPGDOPRM1 | |
| SCHEMBL9535638 | 0.77 | TACR1 (0.39) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0355599-B1 | 3-ARYL-PYRROLIDINE-2,4-DIONES | BAYER AG (DE) | 1993-05-19 | — | — | EP | disclosed |
| EP-0355599-A1 | 3-Aryl-pyrrolidine-2,4-diones | BAYER AG (DE) | 1990-02-28 | — | — | EP | disclosed |