Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537592 | 0.93 | DHODH (0.51) | DHODHNPSR1KDM4EMAPTRECQL | |
| SCHEMBL9536539 | 0.91 | DHODH (0.53) | DHODHNPSR1KDM4EMAPTRECQL | |
| SCHEMBL10824742 | 0.85 | DHODH (0.52) | DHODHNPSR1KDM4EMAPTRECQL | |
| SCHEMBL14700370 | 0.83 | KEAP1 (0.44) | DHODHNPSR1KDM4EMAPTHPGD | |
| SCHEMBL7009563 | 0.83 | NPSR1 (0.41) | DHODHNPSR1KDM4EMAPTHPGD | |
| SCHEMBL7009560 | 0.83 | NPSR1 (0.41) | DHODHNPSR1KDM4EMAPTHPGD | |
| SCHEMBL10372640 | 0.83 | DHODH (0.54) | DHODHNPSR1KDM4EMAPTRECQL | |
| SCHEMBL10372641 | 0.83 | DHODH (0.54) | DHODHNPSR1KDM4EMAPTRECQL | |
| SCHEMBL5258270 | 0.82 | MEN1 (0.43) | DHODHNPSR1KDM4EMAPTHPGD | |
| SCHEMBL5258272 | 0.82 | MEN1 (0.43) | DHODHNPSR1KDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153580-B2 | NAPHTHYRIDINE ANTIBACTERIAL COMPOUNDS | ABBOTT LABORATORIES (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0153580-B1 | NAPHTHYRIDINE ANTIBACTERIAL COMPOUNDS | ABBOTT LABORATORIES (US) | 1989-01-25 | — | — | EP | disclosed |
| EP-0153580-A1 | Naphthyridine antibacterial compounds | ABBOTT LABORATORIES (US) | 1985-09-04 | — | — | EP | disclosed |