Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535935 | 0.93 | DHODH (0.50) | DHODHMAPTNPSR1ALDH1A1MEN1 | |
| SCHEMBL9536539 | 0.92 | DHODH (0.53) | DHODHMAPTNPSR1MEN1KMT2A | |
| SCHEMBL5258272 | 0.88 | MEN1 (0.43) | DHODHMAPTNPSR1ALDH1A1MEN1 | |
| SCHEMBL5258270 | 0.88 | MEN1 (0.43) | DHODHMAPTNPSR1ALDH1A1MEN1 | |
| SCHEMBL7009563 | 0.86 | NPSR1 (0.41) | DHODHMAPTNPSR1ALDH1A1MEN1 | |
| SCHEMBL7009560 | 0.86 | NPSR1 (0.41) | DHODHMAPTNPSR1ALDH1A1MEN1 | |
| SCHEMBL8129004 | 0.86 | NPSR1 (0.57) | DHODHMAPTNPSR1ALDH1A1MEN1 | |
| SCHEMBL9381551 | 0.86 | DHODH (0.54) | DHODHMAPTNPSR1ALDH1A1MEN1 | |
| SCHEMBL9381550 | 0.86 | DHODH (0.54) | DHODHMAPTNPSR1ALDH1A1MEN1 | |
| SCHEMBL14700370 | 0.84 | KEAP1 (0.44) | DHODHMAPTNPSR1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153580-B2 | NAPHTHYRIDINE ANTIBACTERIAL COMPOUNDS | ABBOTT LABORATORIES (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0153580-B1 | NAPHTHYRIDINE ANTIBACTERIAL COMPOUNDS | ABBOTT LABORATORIES (US) | 1989-01-25 | — | — | EP | disclosed |
| EP-0153580-A1 | Naphthyridine antibacterial compounds | ABBOTT LABORATORIES (US) | 1985-09-04 | — | — | EP | disclosed |