Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | FDPS | P14324 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536253 | 0.92 | FDPS (0.45) | USP2KDM4EALOX15HSD17B10RAB9A | |
| SCHEMBL9715445 | 0.83 | L3MBTL1 (0.49) | USP2KDM4EALOX15HSD17B10RAB9A | |
| SCHEMBL10473123 | 0.77 | SMN1; SMN2 (0.57) | KDM4EHSD17B10RAB9ATSHRLMNA | |
| SCHEMBL9537775 | 0.74 | NPC1 (0.52) | ALOX15HSD17B10RAB9ALMNAALDH1A1 | |
| Oxalic Acid SCHEMBL9536039 | 0.73 | KDM4E (0.66) | USP2KDM4EALOX15HSD17B10RAB9A | |
| SCHEMBL2777930 | 0.71 | FDPS (0.58) | RAB9AFDPSALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL30986000 | 0.71 | USP2 (0.60) | USP2KDM4EALOX15HSD17B10RAB9A | |
| SCHEMBL31461158 | 0.69 | KDM4E (0.58) | USP2KDM4EALOX15HSD17B10RAB9A | |
| SCHEMBL13351522 | 0.68 | FDPS (0.59) | KDM4EHSD17B10RAB9AFDPSALDH1A1 | |
| SCHEMBL9539151 | 0.67 | ALDH1A1 (0.48) | USP2KDM4ERAB9AFDPSTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |