Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 6/20 | 0.65 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536186 | 0.94 | MAPT (0.56) | CCR3MAPTTP53POLBSLC6A2 | |
| SCHEMBL10549253 | 0.89 | CCR3 (0.52) | CCR3TMEM97POLBKCNH2 | |
| SCHEMBL9536165 | 0.85 | CCR3 (0.56) | CCR3TMEM97MAPTPOLBSLC6A2 | |
| Oxalic Acid SCHEMBL9538011 | 0.84 | PLD2 (0.47) | CCR3MAPTTP53POLBSLC6A2 | |
| Oxalic Acid SCHEMBL9538009 | 0.84 | PLD2 (0.47) | CCR3MAPTTP53POLBSLC6A2 | |
| SCHEMBL9536847 | 0.84 | KCNH2 (0.49) | TP53POLBKCNH2 | |
| Oxalic Acid SCHEMBL10552513 | 0.83 | SSTR5 (0.51) | TP53KCNH2 | |
| SCHEMBL10547215 | 0.83 | POLB (0.49) | CCR3POLBSLC6A2SLC6A4KCNH2 | |
| SCHEMBL9536213 | 0.83 | TP53 (0.61) | CCR3MAPTTP53POLB | |
| SCHEMBL9539669 | 0.82 | RAB9A (0.52) | TMEM97MAPTTP53SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |