Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537328 | 0.85 | SIGMAR1 (0.46) | DRD2DRD4DRD3HTR1APARP1 | |
| SCHEMBL9537905 | 0.79 | SIGMAR1 (0.47) | DRD2HTR1APARP1SIGMAR1 | |
| SCHEMBL9536484 | 0.79 | SIGMAR1 (0.47) | DRD2HTR1APARP1SIGMAR1 | |
| SCHEMBL10575601 | 0.73 | HSD17B10 (0.46) | DRD2KDM4ELMNA | |
| SCHEMBL9536817 | 0.72 | DRD2 (0.48) | DRD2DRD4HTR1AKDM4ELMNA | |
| SCHEMBL10576624 | 0.72 | DRD2 (0.48) | DRD2DRD4HTR1AKDM4ELMNA | |
| SCHEMBL9535704 | 0.72 | KDM4E (0.59) | DRD2DRD3HTR1AKDM4ELMNA | |
| SCHEMBL10854796 | 0.70 | KDM4E (0.53) | DRD2HTR1AKDM4ELMNAALOX15 | |
| SCHEMBL9535966 | 0.69 | MAPT (0.45) | DRD2DRD4HTR1A | |
| SCHEMBL2395487 | 0.68 | DRD2 (0.59) | DRD2DRD4DRD3HTR1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254623-B1 | AMINOALKYLTHIO TRIAZOLOPYRIDINE OR TRIAZOLOQUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM, PARTICULARLY USEFUL AS ANTALGICS | LABORATOIRES UPSA (FR) | 1993-06-09 | — | — | EP | disclosed |
| EP-0254623-A1 | Aminoalkylthio triazolopyridine or triazoloquinoline derivatives, process for their preparation, medicaments containing them, particularly useful as antalgics | LABORATOIRES UPSA (FR) | 1988-01-27 | — | — | EP | disclosed |