Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 3/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534992 | 0.80 | CDC7 (0.54) | KCNH2CDC7DBF4POLB | |
| SCHEMBL8135558 | 0.80 | KCNH2 (0.45) | KCNH2CDC7DBF4DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9535340 | 0.79 | CDC7 (0.53) | KCNH2CDC7DBF4POLB | |
| Hydrochloric Acid SCHEMBL9535454 | 0.78 | KCNH2 (0.51) | KCNH2CDC7DBF4 | |
| SCHEMBL9536746 | 0.77 | KCNH2 (0.46) | KCNH2CDC7DBF4MAPTLMNA | |
| SCHEMBL9536620 | 0.76 | CDC7 (0.41) | KCNH2CDC7DBF4MAPTLMNA | |
| SCHEMBL27505138 | 0.76 | JAK3 (0.43) | KCNH2CDC7DBF4PDE10A | |
| SCHEMBL9044459 | 0.76 | PTPN11 (0.48) | CDC7DBF4CYP1A2CYP3A4PDE10A | |
| SCHEMBL9689825 | 0.76 | CDC7 (0.47) | KCNH2CDC7DBF4 | |
| SCHEMBL9535712 | 0.75 | KCNH2 (0.75) | KCNH2HTR1AHTR2CHTR3AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295742-B1 | NOVEL N-(4-PIPERIDINYL) BICYCLIC CONDENSED 2-IMIDAZOLAMINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-26 | — | — | EP | disclosed |