Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.38 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689809 | 0.81 | KCNH2 (0.72) | KCNH2TSHRCHRNA7GAAMAPT | |
| SCHEMBL9536746 | 0.79 | KCNH2 (0.46) | KCNH2MAPT | |
| SCHEMBL9690409 | 0.77 | KCNH2 (0.55) | KCNH2TSHRCHRNA7GAA | |
| SCHEMBL9691007 | 0.77 | KCNH2 (0.59) | KCNH2 | |
| SCHEMBL11266594 | 0.76 | KCNH2 (0.80) | KCNH2TSHRCHRNA7GAAMAPT | |
| SCHEMBL9689872 | 0.76 | KCNH2 (0.90) | KCNH2GAAMAPTL3MBTL1 | |
| SCHEMBL9698375 | 0.75 | KCNH2 (0.66) | KCNH2TSHRCHRNA7KCNN3HDAC6 | |
| SCHEMBL9697190 | 0.75 | KCNH2 (0.66) | KCNH2TSHRKCNN3HDAC6 | |
| SCHEMBL7416758 | 0.75 | KCNH2 (0.65) | KCNH2TSHRKCNN3HDAC6 | |
| SCHEMBL8560605 | 0.73 | KCNH2 (0.61) | KCNH2KCNN3HDAC6KCNN1KCNN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297661-B1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-16 | — | — | EP | disclosed |