Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 7/20 | 0.43 |
| ▸ | HTR1A | P08908 | 5/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | DGKA | P23743 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538894 | 0.84 | SLC6A9 (0.44) | HRH1HTR1ADRD2HTR2ALMNA | |
| SCHEMBL9535554 | 0.77 | SLC6A9 (0.52) | HRH1LMNACYP2D6TSHRSMN1; SMN2 | |
| Oxalic Acid SCHEMBL9538798 | 0.77 | SLC6A9 (0.47) | HRH1HTR2ALMNASMN1; SMN2MEN1 | |
| Oxalic Acid SCHEMBL9538801 | 0.77 | SLC6A9 (0.47) | HRH1HTR2ALMNASMN1; SMN2MEN1 | |
| SCHEMBL9685843 | 0.76 | SLC6A9 (0.53) | HRH1HTR1ADRD2HTR2ALMNA | |
| SCHEMBL9538919 | 0.76 | SLC6A9 (0.43) | HRH1LMNAMAPTSMN1; SMN2TP53 | |
| Oxalic Acid SCHEMBL9535426 | 0.75 | SLC6A9 (0.49) | HRH1LMNASMN1; SMN2ALDH1A1TP53 | |
| Oxalic Acid SCHEMBL9535422 | 0.75 | SLC6A9 (0.49) | HRH1LMNASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL8567881 | 0.75 | MAPT (0.44) | HRH1HTR1ADRD2HTR2ALMNA | |
| SCHEMBL9535795 | 0.75 | SLC6A9 (0.45) | HRH1LMNAMAPTSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282133-B1 | 1-ALKYL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-28 | — | — | EP | disclosed |
| US-4943580-A | ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |
| EP-0282133-A2 | 1-alkyl substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-09-14 | — | — | EP | disclosed |