Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5623659 | 0.76 | KDM4E (0.49) | KDM4EMEN1KMT2ACYP1A2MAPT | |
| SCHEMBL9801881 | 0.76 | CYP1A2 (0.37) | KDM4EKMT2ACYP1A2MAPTNAPRT | |
| SCHEMBL29916309 | 0.76 | KDM4E (0.39) | KDM4EMEN1LMNAKMT2AMAPT | |
| SCHEMBL12844511 | 0.75 | ALDH1A1 (0.38) | KDM4EMEN1LMNAKMT2AMAPT | |
| SCHEMBL5561856 | 0.75 | ALDH1A1 (0.38) | KDM4EMEN1LMNAKMT2ACYP1A2 | |
| SCHEMBL28739245 | 0.75 | KDM4E (0.57) | KDM4EMEN1LMNAKMT2ACYP1A2 | |
| SCHEMBL23500680 | 0.74 | LMNA (0.56) | KDM4EMEN1LMNAKMT2AMAPT | |
| SCHEMBL874090 | 0.71 | CYP1A2 (0.50) | KDM4ELMNACYP1A2MAPTNAPRT | |
| SCHEMBL12463791 | 0.70 | KDM4E (0.47) | KDM4EMEN1LMNAKMT2ACYP1A2 | |
| SCHEMBL30513503 | 0.70 | AGBL2 (0.45) | KDM4EMEN1LMNAKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0568540-A1 | 2,4-DIOXO-PYRIDO 2,3-d]PYRIMIDINE-3-ACETIC ACIDS AND ESTERS AND SALTS THEREOF | PFIZER INC. (US) | 1993-11-10 | — | — | EP | disclosed |
| WO-1992012979-A1 | 2,4-DIOXO-PYRIDO [2,3-d]PYRIMIDINE-3-ACETIC ACIDS AND ESTERS AND SALTS THEREOF | PFIZER INC. (US) | 1992-08-06 | — | — | WO | disclosed |