Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | HTR2C | P28335 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | DGKA | P23743 | 1/20 | 0.51 |
| ▸ | DGKG | P49619 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536033 | 0.90 | HRH1 (0.47) | HTR2ACYP1A2CYP3A4HTR1ADRD2 | |
| SCHEMBL9536553 | 0.90 | HTR2A (0.54) | HTR2ACYP1A2CYP3A4HTR1ACYP2C9 | |
| SCHEMBL10550233 | 0.87 | ACHE (0.51) | HTR2ACYP1A2CYP3A4HTR1ACYP2C9 | |
| SCHEMBL9741182 | 0.86 | HRH1 (0.64) | HTR2ACYP1A2CYP3A4HTR1ACYP2C9 | |
| SCHEMBL9535634 | 0.85 | RAB9A (0.46) | HTR2ACYP1A2CYP3A4HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL10548980 | 0.85 | HTR2A (0.41) | HTR2ACYP1A2CYP3A4HTR1ACYP2C9 | |
| SCHEMBL9539277 | 0.85 | ALDH1A1 (0.49) | HTR2ACYP1A2CYP3A4HTR1ACYP2C9 | |
| SCHEMBL9695594 | 0.84 | HTR2A (0.68) | HTR2ACYP1A2CYP3A4HTR1ACYP2C9 | |
| SCHEMBL9697178 | 0.84 | HTR2A (0.56) | HTR2ACYP1A2CYP3A4HTR1ACYP2C9 | |
| SCHEMBL9538447 | 0.84 | GAA (0.52) | HTR2ACYP1A2CYP3A4HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |